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Management Algorithm For mild HS (low IHS4), topical 15% resorcinol has been evaluated in small prospective and long-term studies, showing reductions in pain, lesion size and IHS4 scores, albeit with irritant dermatitis in some patients [83,84,85], while a randomized, double-blind, placebo-controlled pilot trial of botulinum toxin type B and emerging series with botulinum toxin type A have demonstrated meaningful improvements in pain, suppuration and QoL, particularly in patients with concomitant hyperhidrosis [86, 87]

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