Jian Z, Li K, Liu L, Zhang Y, Zhou Z, Li C, et al
Pharmacological induction of 5 alpha-reductase deficiency in the rat: separation of testosterone-mediated and 5 alpha-dihydrotestosteronemediated effects
Puede dar lugar a la enfermedad del hgado graso entre las personas que beben demasiado alcohol e incluso entre las que no beben
Glutamate can then undergo further metabolism to produce important intermediates like -ketoglutarate (-KG), which is a key substrate in the TCA cycle for ATP production and anaplerosis
This leads to enhanced wound healing, stimulation of dermal fibroblasts, and anti-aging effects through extracellular matrix remodeling
In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the ectoenzyme -glutamyl transpeptidase (also called -glutamyl transferase or GGT) (Figure 1C)