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A 2015 review in the Journal of Clinical Endocrinology confirming that GHRH analogs combined with ghrelin-pathway agonists produce a synergistic GH secretory response that exceeds additive effects when either compound is used alone provides the mechanistic basis for why combination therapy is the standard in supervised clinical settings

doi:10.1016/j.jand.2016.09.025

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In fact, such a transporter has been observed in non-fenestrated intracerebral capillaries (173177) and could well be present in glia and/or neurons, providing a possible pathway toward sequestration