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doi: 10.1016/j.cub.2015.04.004 209 WiebeM

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TDP-43 undergoes mislocalization to the cytoplasm of neurons and glial cells, forming insoluble aggregates and inclusion bodies, which contribute to TDP-43 proteinopathies such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration [101, 102]