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Additionally, research has indicated that melatonin may be relatively ineffective, potentially due to treatment periods being either too brief or too prolonged

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Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schuller J, Xu H, Taguchi K, Yamamoto M, Muller T: The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes

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